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Lock a column

Is there a way to lock a column via js or xml or both?

What do you mean by "lock" column?

If you want to lock column position - you can use split mode
    http://dhtmlx.com/docs/products/dhtmlxGrid/samples/frozen_columns/pro_grid_split.html?un=1207300245000

If you want to lock edit operations for column, it can be done with next code
    mygrid.attachEvent("onEditCell",function(stage,id,ind){
       if (ind==SOME)
          return false;
       return true;
    });
where SOME - index of column in question.