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Nested Layouts

I am trying to create a layout similar to the one mentioned in this knowledge base article:http://www.dhtmlx.com/docs/products/kb/index.php?s=normal&q=6985

The layout would contain 4 cells, a,b,c,d.  Two columns: a,b and ONE row. Cells c,d are nested within b.
Here is an image:
http://logical-marketing.com/sites/logical-marketing.com/files/nested_layout.jpg

is this possible?

Yes, you should use 2U pattern for primary layout and 2E pattern for secondary layout (use cell-based init for secondary layout).